運動器疾患の病態解明と治療戦略

Homeostasis and Disorder of Musculoskeletal System.Pathogenesis of musculoskeletal diseases and strategies for their treatment.

　運動器とよばれる骨や筋肉，靭帯，腱などの組織は，加齢などによりその恒常性が破綻し，骨粗鬆症や筋萎縮などに陥る。これまで，これらの組織においては，骨代謝や筋代謝などの面から様々な研究がなされ，多くのことが明らかにされてきた。本稿では，骨粗鬆症および不動性筋萎縮の治療の課題や，我々がこれまで取り組んできたそれらの疾患の病態解明について考察したい。

　Decline of homeostasis in musculoskeletal locomotive organs such as bone and muscle with age leads to age-related diseases such as osteoporosis and muscle atrophy. To date, various findings underlying the pathogenesis of these tissues were accumulated. In this review, we discuss regarding the recent advances in the findings in the treatment for osteoporosis and the strategy for muscle atrophy, and our recent findings on the mechanisms underlying these diseases.