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ゲノムデータが様々な医学や生物学分野で得られるようになったが,それらを統合する概念として,筆者は「六層構造(Six-layer structure)」を発表した。六層は上位層から順に,生命(life),種(species),集団(population),家族(family),個体(individual),細胞(cell)により構成され,上位層の一つの要素が下位層の集合を構成するという構造を持つ。それぞれの層で要素の順位をゲノムデータにより定義できる。このフレームワークによりゲノムが関与する研究,検査,薬物治療を統合的に説明することができ,新たな発見,検査法の樹立,創薬に役立てることができる。
Genomic data are now available from various fields of medicine and biology, and I proposed a conceptual framework “Six-layer structure” to integrate various areas of genomics. The proposed layers are “life” as the uppermost layer, followed by “species”,“population”,“family”,“individual”,and finally “cell” as the bottommost layer. In each pair of adjacent layers, each member of the upper layer comprises a set of members of the lower layer. In each layer, we can define consistent partial orders of members based on genomic data in the forms of phylogenic and pedigree trees. Based on this framework, we can give integrated explanations for various researches, tests and drug therapies concerning genomic data, and we can use this framework for new discoveries as well as new test and drug developments.