大腿骨近位部骨折の予防が可能な薬剤は？

Hip Fracture ― Epidemiology, Management and Liaison Service. Medicines that prevent hip fracture.

　本邦で使用可能な大腿骨近位部骨折の予防可能なエビデンスのある薬剤は，いずれも骨吸収抑制剤であるアレンドロネート，リセドロネートとデノスマブの３剤である。現時点でのエビデンスはないが，骨密度上昇効果から骨吸収抑制剤のデノスマブと骨形成促進剤のテリパラチドの併用療法も大腿骨近位部骨折予防が期待できる。

　Based on the results of numbers of the clinical trials, the medicines that prevent hip fracture are alendronate, risedronate, and denosumab, which are all antiresorptive. Although currently evidence is not available, combination anabolic and antiresoprtive therapy using teriparatide and denosumab is expected to efficiently prevent hip fracture because such therapy increases hip bone mineral density more than either drug alone.