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Current Topics on Vitamin D. Evolution of animals and vitamin D. Suda Tatsuo 1 1Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan pp.349-358
Published Date 2015/2/28
DOI https://doi.org/10.20837/4201503349
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 Vitamin D3 is already found in the early evolution of life, but essentially as inactive products of the photochemical reaction of 7-dehydrocholesterol. The full vitamin D endocrine system characterized by the specific vitamin D transport protein(DBP),specific vitamin D-metabolizing CYP450 enzymes, active vitamin D metabolites,1α,25(OH)2D3, specific vitamin D nuclear receptor(VDR),and fibroblast growth factor 23(FGF23)became essential for maintaining calcium and bone homeostasis in terrestrial animals cope with the challenging of higher gravity and calcium-poor environment. The present review describes the story about the evolution of animals and vitamin D.



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電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社

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