Japanese

Aging and Bio-motor function. Chronic inflammation and organismal aging. T. Atsuhiko 1 , Komuro Issei 2 1Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Japan. 2Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Japan./Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Japan. pp.51-58
Published Date 2012/12/28
DOI https://doi.org/10.20837/4201301051
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 Aging is defined as the progressive functional decline of tissue function accompanied by increasing mortality with advancing age. Many researchers proposed various theories of aging, however, precise molecular mechanism of organismal aging remains elusive. The presence of autoantibody and the concentration of various inflammatory cytokines are often correlated to age, even in healthy individuals who do not have autoimmune or infectious diseases. In addition, low grade chronic inflammation has been regarded as a background for many age-related human diseases. These findings suggest that chronic inflammation plays a causative role in organismal aging and that proper regulation of aged immune system may decelerate organismal aging.



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電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社

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