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A case of adrenal insufficiency after stereotactic body radiation therapy for bilateral adrenal metastases of malignant melanoma Yuta Kimura 1 1Department of Radiology Okayama University Hospital Keyword: 副腎転移 , 副腎機能低下症 , 体幹部定位放射線治療(stereotactic body radiation therapy:SBRT) pp.787-792
Published Date 2025/9/10
DOI https://doi.org/10.18888/rp.0000002975
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A male in his 70s with malignant melanoma of the left hallux developed systemic metastases during postoperative follow-up. The lesions temporarily regressed with pembrolizumab but subsequently developed interstitial pneumonia, necessitating a switch to dacarbazine. Subsequent chemotherapy with dacarbazine maintained shrinkage of the metastases other than bilateral adrenal metastases. Bilateral adrenal metastases showed an increasing trend. Therefore, stereotactic body radiation therapy(SBRT)was performed for both adrenal metastases(30Gy/10fr to the right lesion and 40Gy/10fr to the left). About 2 weeks after irradiation, the patient exhibited fever, fatigue, and anorexia. He was diagnosed with adrenal insufficiency(AI). In this case, AI occurred relatively early compared to previous reported cases.


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電子版ISSN 印刷版ISSN 0009-9252 金原出版

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