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近年,副腎転移への体幹部定位放射線治療(stereotactic body radiation therapy:SBRT)に関する報告が多くされている1)。今回我々は,悪性黒色腫の両側副腎転移にサイバーナイフによるSBRTを行い,副腎機能低下症(adrenal insufficiency:AI)を生じた1例を経験したので文献的考察を加えて報告する。
A male in his 70s with malignant melanoma of the left hallux developed systemic metastases during postoperative follow-up. The lesions temporarily regressed with pembrolizumab but subsequently developed interstitial pneumonia, necessitating a switch to dacarbazine. Subsequent chemotherapy with dacarbazine maintained shrinkage of the metastases other than bilateral adrenal metastases. Bilateral adrenal metastases showed an increasing trend. Therefore, stereotactic body radiation therapy(SBRT)was performed for both adrenal metastases(30Gy/10fr to the right lesion and 40Gy/10fr to the left). About 2 weeks after irradiation, the patient exhibited fever, fatigue, and anorexia. He was diagnosed with adrenal insufficiency(AI). In this case, AI occurred relatively early compared to previous reported cases.

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