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IgG4関連疾患は,血清IgG4高値と組織のIgG4陽性形質細胞浸潤を特徴とする全身炎症性疾患である1)。本疾患は,我が国より発表された新しい疾患概念であり,世界に先駆けて2011年にIgG4関連疾患包括的診断基準2011(厚生労働省 岡崎班・梅原班)が提唱された。IgG4関連疾患では,涙腺・唾液腺,肺,膵,胆管,腎,後腹膜,前立腺,リンパ節などと全身諸臓器に病巣が及ぶため,その炎症性病変の検索に2-[18F]-fluoro-2-deoxy-D-glucose(18F-FDG)positron emission tomography/computed tomography(PET/CT)の有用性が多く報告されている2)3)。
The aim of this study was to compare 18F-FDG PET/CT and 18F-FAMT PET/CT in IgG4-related disease(IgG4-RD). Twelve patients with IgG4-RD underwent both 18F-FDG and 18F-FAMT PET/CT. 18F-FDG and 18F-FAMT uptake were evaluated visually and by SUVmax. Lesion-to-mediastinum(L/M)and lesion-to-liver(L/L)ratios were caluculated. SUVmax of 18F-FDG positive-lesions were significantly higher compared to SUVmax of 18F-FAMT(p<0.05). L/M and L/L were significantly different between 18F-FDG and 18F-FAMT(p<0.05). Diagnostic method by combination of 18F-FDG and 18F-FAMT PET/CT may be useful for differentiating IgG4-RD from tumors.
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