Thyroid transcription factor-1による免疫染色が原発巣の特定に有用であった肺結節

Thyroid Transcription Factor-1 is Useful for Identifying Primary Tumors

肺癌の画像所見は時に炎症性変化との鑑別が困難なため，経過観察とされることがしばしばある．われわれは，肝癌として切除された腫瘍がthyroid transcription factor-1（TTF-1）により肺癌の転移であることが後に判明した症例を経験したので報告する．

A 67-year-old man had underwent liver resection 3 years previously. The pathological diagnosis was intrahepatic cholangiocarcinoma. However, a follow-up computed tomography （CT） scan revealed gradual enlargement of the pulmonary nodule left S1＋2 and he was performed surgery. Because the metastasis of intrahepatic cholangiocarcinoma was demonstrated for lymph node （LN） #3 by intraoperative rapid pathology, only the left upper lobe was resected. Finally, the postoperative pathological diagnosis by thyroid transcription factor-1 （TTF-1） staining was primary lung cancer. Liver lesion was also diagnosed as liver metastases of the lung cancer by TTF-1 staining.