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Japanese

Pulmonary Adenocarcinoma with Heterotopic Ossification Jun Suzuki 1 , Naoki Kanauchi 2 , Makoto Endo 3 , Akira Hamada 4 , Hikaru Watanabe 5 1Department of Thoracic Surgery, Nihonkai General Hospital Keyword: lung cancer , adenocarcinoma , heterotopic ossification pp.363-366
Published Date 2019/5/1
DOI https://doi.org/10.15106/j_kyobu72_363
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Background:Although malignant tumor with heterotopic ossification have often been reported, it is very rare in lung cancer. We report a case of primary lung adenocarcinoma with heterotopic ossification.

Case:A 43-year-old woman undergoing a health check was found an abnormal nodular lesion on chest X-ray. Chest computed tomography (CT) showed a calcified tumor, which was diagnosed adenocarcinoma by transbronchial biopsy. Right lower lobectomy and ND2a-2 lymph node dissection was done. Postoperative pathological examination identified the tumor as a bronchioloalveolar adenocarcinoma with other mixed subtypes, associated with ossification containing bone marrow tissue in the tumor. An immunohistochemical examination showed that cancer cells around the ossification expressed bone morphogenetic protein-2 and osteopontin, which generally induce and stimulate bone formation.

Conclusion:This finding may serve to elucidate a probable mechanism for the heterotopic ossification observed in cancer lesions.


© Nankodo Co., Ltd., 2018

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電子版ISSN 2432-9436 印刷版ISSN 0021-5252 南江堂

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