Psychological Distress and Feelings of Guilt after Disclosure of Genetic Test Results Regarding Hereditary Nonpolyposis Colorectal Cancer Yoshie Murakami 1 1Adult Nursing, Graduate School of Human Health Sciences, Tokyo Metropolitan University Keyword: 遺伝性腫瘍 , 遺伝子検査 , 精神的苦痛 , 罪責感 , cancer genetics , genetic testing , psychological distress , guilt pp.23-31
Published Date 2010/9/21
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 Purpose:To reveal psychological distress and feelings of guilt of probands and unaffectedrelatives at 1 and 12 months after the disclosure of genetic test results regarding hereditarynonpolyposis colorectal cancer (HNPCC).

 Methods:Participants of the research were probands who fulfilled HNPCC criteria andtheir unaffected relatives. The participants consisted of those who visited the outpatient clinicfor cancer genetics, and those who were underwent a genetic test for HNPCC. The structuredclinical interview was used in order to investigate psychological distress of probandsand unaffected relatives at 1 and 12 months after the disclosure of genetic test results regardingHNPCC. The feelings of guilt were also investigated using semistructured interviews.This is a descriptive prospective cohort study.

 Results:The object of analysis was 30 who completed the final interview conducted 12months after the disclosure of genetic test results for HNPCC. The disclosure of genetic testresults related to HNPCC did not have a significant psychological impact, as none of theprobands or relatives met the criteria at the time of the 1-month or 12-months follow-up interview.It was revealed that predictive factor for long-term psychological distress was theparticipants' innate psychological weakness. Feelings of guilt were observed regardless ofgenetic test results.

 Conclusion:This suggests that nurses who are in charge of genetic counseling should assesswhether or not psychological weakness is observed within probands or their relativesas soon as possible, and set up a system to provide long-term support.

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