INTENSIVIST Volume 11, Issue 1 (January 2019)

Treatment of seasonal influenza Yoshiki KUSAMA 1 , Satoshi KUTSUNA 2 1Disease Control and Prevention Center National Center for Global Health and Medicine/AMR Clinical Reference Center 2Disease Control and Prevention Center National Center for Global Health and Medicine pp.115-124
Published Date 2019/1/1
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Seven anti-seasonal influenza drugs, including amantadine, oseltamivir, zanamivir, laninamivir, peramivir and baloxavir, are currently available in Japan. However, there is insufficient evidence for clinical effects of these drugs against seasonal influenza. Especially in critically ill patients, the appropriate treatment of seasonal influenza is undefined. Early administration of anti-seasonal influenza drugs is recommended for pediatric, pregnant, elderly, and facility resident patients who have risk factors for the development of flu-related complications. In the 2007-2008 season, oseltamivir-resistant seasonal influenza, Russian A (H1N1) type, spread worldwide from Norway. This resistant seasonal influenza is no longer prevalent because the virus was replaced by influenza A (H1N1)pdm09. However, further monitoring is needed. Baloxavir became available for seasonal influenza in 2018, but current evidence shows that it should only be given to healthy individuals for now. Therefore, we should cautiously use this drug, especially when administering it to critically ill patients. Since antibiotic resistance is a global concern, antibiotics should be administered only when evidence of bacterial infections is found in patients with seasonal influenza. Currently, routinely adding vancomycin as empiric therapy against a bacterial pneumonia co-infection with seasonal influenza is not recommended. Monitoring the epidemiology of methicillin-resistant Staphylococcus aureus prevalence is important.

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11巻1号 (2019年1月)
電子版ISSN 2186-7852 印刷版ISSN 1883-4833 メディカル・サイエンス・インターナショナル