青年男性の血中コレステロールとその後の心臓血管病変

SERUM CHOLESTEROL IN YOUNG MEN AND SUBSEQUENT CARDIOVASCULAR DISEASE

　背景．中年者における血中コレステロール値の増加が心臓血管病変リスクの上昇をもたらすことはすでに明確に確に立されているが，若年男性の血中コレステロール値と将来の臨床上明らかな心臓血管病変の罹患率との間の関連性の有無を検討する機会はあまりない．

　方法．われわれは1,017名の若い男性（平均年齢22歳）を27から42年にわたって成人早期における血中コレステロール値と心臓血管疾患の危険率および総死亡率との関連性を明らかにするため前向き調査を行った．開始時の平均コレステロール値は192mg/dlであった．

　Background. The increased risk of cardiovascular disease associated with higher serum cholesterol levels in middle-aged persons has been clearly established, but there have been few opportunities to examine a potential link between serum cholesterol levels measured in young men and clinically evident premature cardiovasucular disease later in life.

　Methods. We performed a prospective study of 1017 young men (mean age, 22 years) followed for 27 to 42 years to quantify the risk of cardiovascular disease and total mortality associated with serum cholesterol levels during early adult life. The mean serum cholesterollevel at entry was 192 mg per deciliter (5.0 mmol per liter).