高度肥満女性における体重減少の組成：古い方法の新しいみかた

Composition of Weight Loss in Severely Obese Women: A New Look at Old Methods

　7人の食事療法中の高度肥満者の体重が減少し（平均±標準偏差，14±1kg），その体重減少の内訳を6つの違った方法で測定した．総体水分（TBW），総体カリウム（TBK），体比重，骨塩成分と二重光子吸光光度法（DPA）で測定した体脂肪を減量前と後の体重安定期に測定した．脂肪喪失は3つの2コンパートメント法（2C-TBW，2C-TBK，水密度法［2C-HD］），1つの3コンパートメント法（除脂肪重量の水成分による補正を行ったHD法）と1つの4コンパートメント法（除脂肪重量を水分と無機質量による補正を行ったHD法，4C）で計算し，ならびに二重光子吸光光度計で直接測定した．体重喪失は2C-TBK法（体重減少の66％が脂肪）以外のいずれのモデルでも似通った結果となった（平均体重減少の脂肪分はDPA法で89％，4Cで91.5％，3Cで89％，2C-HDで88.6％，2C-TBWで87％）．多コンパートメントモデル（63〜112％）やDPA法（76〜107％）に比較して2C-TBW法や2C-TBK法（それぞれ17〜138％と18〜93％）を用いた場合では個人の値はさらに広い変動幅を示した．同一個人についても2C-TBK法と2C-TBW法を用いた場合ではほとんど反対の結果となった．

Seven severely obese, outpatient dieters lost weight (mean±SEM, 14±1 kg), and the composition of weight lost was determined by six different models. Total body water (TBW), total body potassium (TBK), and body density, bone mineral content, and fat as determined by dual photon absorptiometry (DPA) were measured while subjects were weight-stable, before and after weight loss. Fat loss was calculated by three two-compartment models(2C-TBW, 2C-TBK, andhydrodensitometry [2C-HD]), one three-compartment model(HD withcorrection for water content of fat-free mass[FFM], 3C), and one four-compartment model(HD with correction for water and mineralcontent of FFM, 4C), and was measured directly by DPA. Meancomposition of weight loss was similar for all models(mean weightlost as fat: 89 % for DPA, 91.5% for 4 C, 89% for 3 C, 88.6% for 2C-HD, and 87% for 2 C-TBW) except 2 C-TBK (weight lost as fat, 66%). There was a much wider range of individual values for the 2 C-TBW and 2 C-TBK models (17% to 138% and 18% to 93%, respectively) than for the multicompartment models (63% to 112%) andDPA (76% to 107%). Almost opposite results were obtained for thesame individual when using the 2 C-TBK and 2 C-TBW models.