薬物による臨床化学における分析障害

Analytical Interferences of Drugs in Clinical Chemistry:E. Panek, D.S. Young, J. Bente

　臨床検査室において，ある種の化学的成分の濃度，ならびに酵素活性を測定する分析方法に対する種々の薬物の影響が検討された．薬物は報告されている中毒濃度でまず研究されたが，もしこの濃度で影響がある場合には，更に低濃度でもまた検討された．薬物はまずTechnicon SMAC^TMアナライザーを用いて研究された．次いでDu PontACAならびにTechnicon Auto Analyzer^TMIまたはⅡを用いる方法が検討された．最も多く影響を受ける方法は尿酸測定の際のリンタングステン酸還元法である．しかし，アルカリホスファターゼ，乳酸脱水素酵素測定と同じく，全タンパク量，ならびにアルブミン測定法もしばしば影響を受けた．

The effects of several drugs were tested on analytical methods used in the clinical laboratory to measure the concentration of certain chemical constituents and activity of enzymes in body fluids. Drugs were studied initially at reported toxic concentrations, but if they had an effect at this level, effects of lower concentrations were also investigated. The drugs were first studied on the methods of the Technicon SMAC^TM analyzer. Subsequently, methods in use with the Du Pont ACA and Technicon Auto Analyzer^TM I or II were evaluated. The most commonly affected method was the phosphotungstate reduction procedure for measuring uric acid. However, methods for measuring total protein and albumin were also affected frequently, as were determinations of alkaline phosphatase and lactate dehydrogenase activity.