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G protein-coupled receptors and bioactive lipid mediators Takehiko Yokomizo 1 1Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University Keyword: エイコサノイド , リゾリン脂質 , Gタンパク質共役型受容体 pp.117-124
Published Date 2012/2/15
DOI https://doi.org/10.11477/mf.1542102911
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Recent molecular biology techniques enabled us to reveal the functions of bioactive lipid mediators and their receptors. Lipid mediators transduce signals through either membrane receptors or nuclear receptors, and recently certain lipids derived from cholesterol were found to activate both of them. All the membrane receptors for lipid mediators are G protein-coupled receptors (GPCRs). Recent crystallographic analysis revealed the dynamic structural change of GPCR upon ligand binding using β2 adrenergic receptor as a model. Highly sensitive mass spectrometry is useful for the identification of novel bioactive lipids, and will be used in laboratory tests for diagnosis in the near future.


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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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