Immunosuppressive drugs in the treatment of autoimmune diseases Tohru Akahoshi 1 , Tsuyoshi Takemoto 1 1Department of General Medicine, Kitasato University School of Medicine Keyword: 免疫抑制薬 , 自己免疫疾患 , 膠原病 pp.1343-1348
Published Date 2011/10/30
DOI https://doi.org/10.11477/mf.1542102822
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Autoimmune diseases are abnormal immune reactions against self antigens. In the treatment of autoimmune diseases, glucocorticoid hormones as well as immunosuppressive drugs are predominantly used to suppress increased immune responses and inflammation. Three kinds of immunosuppressive drugs, alkylating agents, purine analogues, and calcineurin inhibitors, are widely used for the treatment of autoimmune diseases as well as various cancers and transplantation. Since these drugs exhibit potent pharmacological effects on various types of cells, they may be life-saving drugs, but they also can induce life-threatening adverse effects. Understanding of the clinical pharmacology of immunosuppressive drugs is essential in the treatment of autoimmune diseases.

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