Autoimmunity Kazuyoshi Ishigaki 1 , Keishi Fujio 1 , Kazuhiko Yamamoto 1 1Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo Keyword: 自己免疫 , 免疫寛容 , Toll like receptor pp.1046-1054
Published Date 2011/10/30
DOI https://doi.org/10.11477/mf.1542102784
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Autoimmunity is an abnormal state in which the immune system recognizes self-tissues as foreign agents and attacks them. The detailed pathophysiology of autoimmunity has not been well elucidated so far despite intensive study. Recently, a lot of new findings in immunology suggest that innate immunity has a significant role in the development of autoimmunity and augments adaptive immunity reacting to self-tissues. Although there are several differences between human autoimmune diseases and mouse disease models, most findings of autoimmunity have been derived from mouse studies. It is our challenging goal to decipher the Enigma of human autoimmunity.

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