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Innate immunity Masanaka Sugiyama 1,2 , Tsuneyasu Kaisho 1,3 1Laboratory of Immune Regulation, WPI Immunology Frontier Research Center, Osaka University 2Research Unit for Inflammatory Regulation, RIKEN Research Center for Allergy and Immunology 3Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology Keyword: パターン認識受容体 , 樹状細胞 , 核酸系免疫アジュバント pp.1055-1063
Published Date 2011/10/30
DOI https://doi.org/10.11477/mf.1542102785
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In the innate immune system, macrophages and dendritic cells recognize pathogen-associated molecular patterns (PAMPs) by pattern-recognition receptors (PRRs) such as Toll-like receptors (TLRs), produce inflammatory cytokines and type I interferons, and prime antigen-specific adaptive immunity by presenting antigen to T lymphocytes. TLR1, TLR2, TLR4, TLR5 and TLR6 are located in the cell surface and recognize bacterial cell surface molecules. TLR3, TLR7 and TLR9 are located in the endosome and recognize microbial nucleic acids, but sometimes TLR7 and TLR9 recognize self DNA or RNA. Recognition of self molecules by TLRs is regarded to be essential for the pathogenesis of autoimmune diseases such as systemic lupus erythematosus and psoriasis vulgaris.


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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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