Role of cytokines in allergic responses Yukari Asai 1 , Hiroko Kitajima 1 , Hiromasa Inoue 1 1Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University Keyword: Th2 , asthma , IL-13 , IL-18 , IL-33 pp.630-635
Published Date 2010/6/15
DOI https://doi.org/10.11477/mf.1542102314
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T cell-derived T-helper type 2(Th2)cytokines such as IL-4, IL-5 and IL-13, are essential for generating the pathophysiological features of allergic disorders, including asthma. These cytokines activate the signal transduction pathways and the negative regulators of pathways. Besides these classic Th2 cytokines, IL-18, a new Th2-cytokine IL-25, and one of the Th2-associated cytokines IL-33 are now recognized as important contributors to allergic inflammation.

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