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A Clinical Analysis of Patients with Primary Intracranial Germinomas : the relationship between proliferative potential and recurrence Katsuzo KUNISHIO 1 , Kengo MATSUMOTO 1 , Tomohisa FURUTA 1 , Takashi OHMOTO 1 1Department of Neurological Surgery, Okayama Medical School Keyword: germinoma , chemotherapy , recurrence , MIB−1 pp.127-132
Published Date 1999/2/10
DOI https://doi.org/10.11477/mf.1436901675
  • Abstract
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We analyzed clinically 30 germinomas (22 pure germinomas and 8 germinomas with syncytiotropho-blastic giant cell (STGC)) and also investigated the proliferative potential of 18 germinomas immuno-histochemically using MIB-1 monoclonal antibody in formalin-fixed paraffin-embedded sections.

The majority of patients responded favorably and completely to the treatment. Seven patients (four hadgerminomas with STGC and the other three had pure germinomas) suffered recurrence after a completeresponse to radiotherapy and/or chemotherapy. The patients with germinomas with STGC experienced re-currence significantly more often than those with pure germinomas (P<0.01). Three of the patients died. The MIB-1 indexes of the germinomas ranged from 18% to 80%. The average MIB-1 index of pure ger-minomas is 58.5±17.3%, that of germinomas with STGC is 45.3±17.1%. There was no significant differ-ence between the two groups. The MIB-1 indexes of 3 recurrent cases were 64.3%, 51.9%, and 20.8%, re-spectively. There were no significant differences in the MIB-1 indexes between nonrecurrent cases and re-current ones.


Copyright © 1999, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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