Metaplastic bone formationを伴う脳室内腫瘍の1例

Subependymal tumor with metaplastic bone formation:a case report

I．はじめに

　神経膠腫内の石灰化はしばしば観察されるが，間質系成分である骨形成を観察することは極めてまれである．今回，結節性硬化症（TSC）が疑われる患者に合併した脳室内腫瘍で腫瘍の病理診断がsubependymal giant cell astrocytomaでなく，しかも標本上にbone formationが観察された症例を経験したので報告する．

A 26-year-old woman was admitted to our hospital because of headache. CT scan and MRI showed a rightsubependymal nodule and a left ventricular tumor, neither of which had any enhancement nor were they stained in angiography. Although no skin abnormality was detected, the patient was suspected of tuberous sclerosis. The diagnosis was made because of the sub-ependymal nodule on CT scan and MRI. On June 29, 1995, total removal of a left ventricular tumor was per-formed by a transcortical approach. Histological sec-tions of this tumor consisted of astrocytic and mening-othelial components, containing metaplastic bone formation. Histological diagnosis was dysplastic sub-ependymal tumor. Postoperative course was uneventful. Regrowth of the tumor has not been observed as of now. This case was suspected to involve factors of tuberous sclerosis from a subependymal nodule. However, the ventricular tumor was not diagnosed as a subependymal giant cell astrocytoma.