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A case of intradural xanthogranuloma in the upper cervical spine Hirofumi OYAMA 1 , Kou IKEDA 1 , Shigeo INOUE 1 , Tsugio KATSUMATA 1 , Sakae MURAKAMI 2 , Akinari DOI 1 1Department of Neurosurgery, Chukyo Hospital 2Department of Pathology, Chukyo Hospital Keyword: xanthogranuloma , spine , Touton cell , CD68 , S−100 protein pp.745-748
Published Date 1997/8/10
DOI https://doi.org/10.11477/mf.1436901437
  • Abstract
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An 18-year-old female patient suffered from posterior neck pain and gait disturbance. The neurological ex-amination revealed left hemiparesis, general hyperreflex-ia and hypoalgesia on the right neck and upper limb, and left trunk and lower limb. MRI showed a large mass lesion in the right side of the spinal canal at the level of the C1 cervical spine, which was obviously compressing the spinal cord. An operation was per-formed through a right suboccipital craniectomy and right hemilaminectomy of the first vertebra. Though the mass lesion in the subarachnoid space compressed the spinal cord, it adhered neither to the spinal cord nor to the nerve roots. However, as it clearly adhered to the dura mater, the attachment site was also completely removed. In the pathological examination, lymphocyte, foamed macrophage and the giant cell of Touton type were shown. The immunohistochemical study with CD68 (Kp1) was positive, but it was negative for the lysozyme, neuron specific enolase and S-100 protein. The diagnosis was xanthogranuloma. The patient reco-vered completely after the operation. This is a rare case of juvenile type xanthogranuloma. This lesion in the spinal canal has usually its onset in the adult age.


Copyright © 1997, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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