脳動脈瘤と腸内細菌・口腔内細菌との関連性

Association of Gut and Oral Microbiota with Cerebral Aneurysms

Point

・口腔内細菌や腸内細菌は脳動脈瘤の発生・破裂に関与している．

・腸内細菌はくも膜下出血後の急性期脳損傷に関与している．

　In recent years, the association of the microbiome with various diseases has been reported. The oral and gut microbiomes have been linked to cerebral aneurysms and are involved in the systemic inflammatory response, which is mediated mainly via the immune system. Chronic inflammation plays an important role in the pathogenesis and rupture of cerebral aneurysms, and the microbiome is potentially involved in this process. Moreover, the gut microbiome is involved in acute brain injury following subarachnoid hemorrhage. Thus, further studies on microbiome-targeted treatments for cerebral aneurysm are required.