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Inflammatory Responses in Hemorrhagic Stroke Tomomichi KAYAHARA 1,2 , Masahiko ITANI 1,3 , Tomohiro AOKI 1 1Department of Pharmacology, The Jikei University School of Medicine 2Department of Cerebrovascular Surgery, Saitama Medical University International Medical Center 3Department of Neurosurgery, Kyoto University Graduate School of Medicine Keyword: 脳動脈瘤 , くも膜下出血 , 脳内出血 , 急性炎症 , 慢性炎症 , intracranial aneurysm , subarachnoid hemorrhage , intracranial hemorrhage , acute inflammation , chronic inflammation pp.931-940
Published Date 2023/9/10
DOI https://doi.org/10.11477/mf.1436204836
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 Inflammation is triggered by various intrinsic and extrinsic stimuli as a protective machinery to maintain homeostasis in the human body. Usually, it is magnified in intensity initially and regresses rapidly afterwards; this phenomenon is called acute inflammation. However, it occasionally lasts a long time; this phenomenon is called chronic inflammation. Induction of some specific machineries, i.e., formation of a positive feedback loop, inflammatory cell infiltration, and changes in tissue architecture, is required for the transition to chronic inflammation; this differentiates chronic and acute inflammation in nature. Chronic inflammation is a common pathogenesis of various diseases, including cancer, vascular disease, and stroke. Recent experimental studies have clarified the crucial role of inflammatory responses in the development and progression of hemorrhagic stroke mediated by tissue destruction or some other aspects of diseases. In this review, we summarize the research findings of the role of inflammation in hemorrhagic stroke.


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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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