雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Prognostic Impact of Radiation Therapy and Molecular Classification of Infant Atypical Teratoid/Rhabdoid Tumors Yoshihiro OTANI 1 , Tomotsugu ICHIKAWA 1 , Kazuhiko KUROZUMI 1 , Takao YASUHARA 1 , Kana WASHIO 2 , Akira SHIMADA 2 , Norihisa KATAYAMA 3 , Kuniaki KATSUI 4 , Hiroyuki YANAI 5 , Isao DATE 1 1Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science 2Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science 3Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science 4Department of Proton Beam Therapy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 5Department of Pathology, Okayama University Hospital Keyword: atypical teratoid/rhabdoid tumor , radiation , genetic analysis pp.147-154
Published Date 2017/2/10
DOI https://doi.org/10.11477/mf.1436203466
  • Abstract
  • Look Inside
  • Reference

 Atypical teratoid/rhabdoid tumor(AT/RT)is a rare and lethal childhood cancer. Although radiation therapy in children less than three years of age is generally deferred because of its neural toxicity, recent studies have shown that multimodal therapies, including radiation therapy, are effective in pediatric patients with AT/RT less than three years of age. We treated four infant AT/RT patients and investigated the impact of radiation therapy and genetic classification on the prognosis. The mean age at the time of the operation was 9.3 months and all patients were female. All patients underwent surgical resection. Of the four patients, two received combined irradiation and chemotherapy. Specifically, one patient received conformal craniospinal radiation therapy and the other received craniospinal irradiation with proton beams. Immunohistochemical analyses of tumor specimens revealed that the two patients were positive for ASCL1, a regulator of Notch signaling. Patients who received radiation therapy and exhibited ASCL1-positive tumors had a better prognosis. We conclude that radiation therapy may prolong survival in AT/RT patients who are less than 3 years of age. However, further study is required to evaluate long-term functional outcomes.


Copyright © 2017, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

関連文献

もっと見る

文献を共有