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I.はじめに
水溶性造影剤metrizamideのすぐれている点はいうまでもなく,現時点ではかけがえのないものである.しかし,使用経験が増すにつれ,種々の副作用報告がみられ,われわれは1981年2月以来の自験例(脊髄腔造影70例,脳槽造影18例,脳室撮影6例)94例中1例に,metrizamide脳症と思われる苦い経験をした.二度とこのようなことがないために,その予防と治療について文献的考察を加え,報告する.
We experienced with a case of 64 year-old man whodeveloped a bizarre disturbance of consciousness aftera metrizamide cervical myelography with a dose of3.6 gram iodide. He was restless, irritable andaphasic. After treatment with intravenous hydrationand compulsive excretion of urine, he could haverecovered gradually from this state by 7 hours, and hegained almost full consciousness by 17 hours. BrainCT taken at 20 hours after metrizamide myelographyshowed high density area in the cerebral cortex, whichwas thought to he due to penetration of metrizamide.
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