頭蓋内クモ膜下腔におけるDimer-X®（第1報）—その毒性

Dimer-X® in the Intracranial Subarachnoid Space: its Toxicity

Ⅰ．はじめに

　空気脳室造影の不確実さ，不鮮明さおよび油性造影剤使用時の操作のやっかいさなどのため，水溶性造影剤の出現とともに最近では前二者にかわり，水溶性剤が脳室造影に使用されることが多くなってきた．

　しかし使用例の増加とともに，種々の副作用の出現が報告されつつあり，ことに脳室造影術後の痙攣発作の出現がその最も重篤なものとして注目されている．これは種々の抗痙攣剤治療に抵抗し，まれならず患者は死に至るといわれている．

The reaction of the rats to injection of Dimer-X^® into the intracranial subarachnoid space or the cerebrum was examined. When 28% iodine Dimer-X was injected into the subarachnoid space, 7 of 10 rats showed agitation, which is the most severe complication, and all died within one hour. All of the reactions were reduced with the lower concentrations of Dimer-X. The rats which were premedicated with Valium^® and/or Decadron^® revealed fewer and less severe complications. It is believed that the intracerebral injection method has many disadvantages, the results of its experiment are therefore reported without further elaboration.