Neurological Surgery No Shinkei Geka Volume 33, Issue 12 (December 2005)

Study on Hemosiderin Deposition after Intracerebral Hemorrhage Kentaro TOYAMA 1 , Toshio IMAIZUMI 1 , Kazuhisa YOSHIFUJI 1 , Kei MIYATA 1 , Maiko KAWAMURA 1 , Ikuhide KOHAMA 1 1Department of Neurosurgery,Kushiro City General Hospital Keyword: hemosiderin , MRI , stroke , ICH pp.1177-1181
Published Date 2005/12/1
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Background and Purpose Hemosiderin degenerated from intracerebral hematoma (ICH) can be visualized as low intensity on gradient-echo T2*-weighted (T2*-w) MRI,which is sensitive for hemosiderin. We studied the factors associated with the hemosiderin deposition on T2*-w MRI after ICH.

Methods We analyzed T2*-w MRIs in 72 outpatients with past ICH (46 males,26 females,28 - 89 (60.0±9.8) years old) consecutively came to our hospital. The odds ratio (OR) for the apparent thickness ≧2.5 mm of low intensity surrounding ICH cavity was estimated,using the time after the onset of ICH (17 weeks - 26 years),and other factors.

Results All of old ICHs were visible as low intensities on T2*-w MRI. Multivariate logistic regression analysis revealed that an elevated ratio of the apparent thickness ≧2.5 mm of hemosiderin was found for the patients with time ≧5 years between T2*-w MRI and the onset (odds ratio (OR): 0.24,95% confidence interval (CI): 0.06-0.99),intraventricular or subarachnoid hemorrhage related to ICH (OR: 0.16,95% CI: 0.03 - 0.77),and the diameter of ICH ≧2cm (OR: 33.7,95% CI: 4.6 - 245).

 Conclusion Though small sample size limited the power of analyses,our findings suggest that the amount of hemosiderin deposition after ICH may be associated with the time after the onset,intraventricular or subarachnoid hemorrhage related to ICH,and the diameter of ICH.

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Neurological Surgery 脳神経外科
33巻12号 (2005年12月)
電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院