ヒト脳各部位の遊離アミノ酸について

Studies on Free Amino Acids in Human Brain.

1）ヒトについて遊離アミノ酸の脳内分布をしらべた。2）ヒト脳の各アミノ酸量はわれわれが検索した脊椎動物のうちではイヌ脳のそれに最も近いが，かなり大量のシスタチオニンが存在する例がある。3）脳内で局所的濃度差が最も著るしいのはγ-アミノ酪酸である。4）種々の疾患ならびに事故死の脳内シスタチオニン量を測定し，個個の例により著しい差異があることを認めた。5）胎児脳の各部位のアミノ酸は成人のそれとは著しく異なることを認めた。

　1. The analysis of amino acids in the protein-free extracts of the human brain has been carriedout by means of ion exchange chromatography.

　2. The various areas of brains were obtainedfrom the individual dying of accident, from fetuseson the fifth and eighth gravid months.

　3. In general the distribution pattern of thefree amino acids in the various areas of the humanbrains resembled that in clog. Gaba was detectedin a large amount in the globus pallidus and thehypothalamus.

　4. We found marked variations of the cystathionine contents in the brains of different individuals.

　5. The quantities of free amino acids in thefetal brains differ significantly from those in themature human brain. Taurine and phosphoethanolamine were detected in a larger amount andglutamic acid, aspartic acid, Gaba and N-acetyl-aspartic acid were detected in smaller amounts.