雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Neuropeptide receptors in the brain. Norio OGAWA 1 1Institute for Neurobiology, Okayama University Medical School pp.91-99
Published Date 1989/2/10
DOI https://doi.org/10.11477/mf.1431906265
  • Abstract
  • Look Inside

Though the definition of brain hormones varies, they usually indicate neuropeptides or brain-gut peptides. Neuropeptides in the brain account for only 1/1,000 of biogenic amines but show marked physiological activity. The distribution of neuropeptides in the brain is not in parallel with that of their receptors with a 40-fold difference being observed in some areas. In biochemical studies of the brain, the amount of neuropeptides have been conventionally measured in an attempt to interpret all brain functions. However, the content of neuropeptides is the sum of their synthesis, storage and release, and there is a possibility that extremely small increases or decreases in their release are overlooked because of large amounts in storage. On the other hand, receptors are localized only in the synaptic area and sensitively reflect functional changes in this area. When release of a neuropeptide increases, the number of receptors decreases (down-regulation), whereas with long-term decreases in release, the number of receptors increases (up-regulation). Therefore, simultaneous measurements of the concentration of neuropeptides and their receptor bindings may provide more accurate information. Since the measurement of receptor binding more sensitively reflects changes in pathophysiological status and those due to drugs, it is essential for evaluation of brain function. In recent years, not only receptors but also the second messenger system has been actively studied. The second messenger system for neuropeptides includes, as with other neurotransmitters, the adenylate cyclase system and the inositol phospholipid system. Recently reciprocal regulation between neuropeptide receptors via the second messenger system has been demonstrated. In addition, reciprocal regulation between neuropeptide receptors and those of classical neurotransmitters have been shown. Interaction between receptors is, together with coexistence of neurotransmitters, an important theme to be solved.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

関連文献

もっと見る

文献を共有