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Transplantation of embryonic medulla and cerebella into adult rat cerebellum. Haruyuki KANAYA 1 , Yasufumi KIKUCHI 1 , Toshiyuki NANAMI 1 , Akira KITAKAMI 1 1Department of Neurosurgery, School of Medicine, Iwate Medical University pp.762-772
Published Date 1988/10/10
DOI https://doi.org/10.11477/mf.1431906225
  • Abstract
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For obtaining fundamental data on the neural transplantation and the interaction between host and transplants some experiments using rats were performed. Pieces of developing medulla oblon-gata or cerebellar primordia were prepared from 13-20 day (E13 to E20) rat embryos and trans-planted to the cerebellum of 6-8 week old rats (Fischer 344). The host animals were maintained for 4 to 9 months after the transplantation. The cytoarchitectonic organization of the transplant were analysed by Nissl (Thionin) staining method, and silver impregnation method (Parmgren) using light microscope. The fine structure of the graft were also analysed using electron microscopy. In the transplantation of embryonic cerebella into adult rat cerebella, the donor tissue developed and differentiated to form folia with the trilaminar organization of the cerebellar cortex. Synaptic connections between neuronal elements in the graft showed basically the normal pattern. Thus, mossy terminals formed synaptic contacts with dendrites of granule cells, and axons of basket cells made synaptic contacts with somata of Purkinje cells. Many spines of Purkinje dendrites were contacted with parallel fibers, while others were surrounded by processes of astroglia.


Copyright © 1988, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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