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Cerebral circulation and metabolism in cerebral ischemia: With particular reference to pH homeostasis. Kortaro TANAKA 1 , Fumio GOTOH 1 1Department of Neurology, School of Medicine, Keio University pp.235-247
Published Date 1988/4/10
DOI https://doi.org/10.11477/mf.1431906182
  • Abstract
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 The mechanism of pH homeostasis in braintissue and its derangement in brain ischemia were reviewed. The four major mechanisms contribute to the maintenance of pH in the normal brain : 1) production and consumption of H+ by brain metabolism, 2) physicochemical buffering, 3) transmembrane trantport of H+ and its equivalent, 4) compensatory adaptation of circulatory factors.

 In brain ischemia, activation of anaerobic glycolysis together with hydrolysis of its product (ATP) is a major factor which produces H+ depending on intracellular pH. Consumption of H+ by metabolism of creatine phosphate and glycogen, or oxidation of lactate is almost negligible under ischemic condition.


Copyright © 1988, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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