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On the treatment of viral infections in the CNS. Yuzo IWASAKI 1 1Department of Neuropathology, Institute of Brain Diseases, Tohoku University School of Medicine pp.996-1002
Published Date 1986/12/10
DOI https://doi.org/10.11477/mf.1431905844
  • Abstract
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 On March 1, 1886, Louis Pasteur concluded his monumental speech at the Academy of Sci-ences in Paris by proclaiming that la prophylaxie de la rage apres morsure est fondèe. An era of vaccine treatment for viral infections in the CNS thus began. What Pasteur left for us was, indeed, great. Without vaccine, we might not be able to control the rabies endemic in Japan during the post-World War period. And fortunately, our land has been free from rabies for the past 25 years. Vaccination also made a great contribution to the management of Japanese encephalitis in Japan. In 1924, the number of patients exceeded 7, 000 and a mortality rate was more than 60% contrasting the number of reported cases being 31 in 1983. Not only for these acute infections but also for slow virus infections, vaccination appears to be effective. After mass vaccination for measles, a significant reduction in the occurrence of subacute sclerosing panencephalitis has been noted in both the U.S.A. and Japan. Thus, the first century of immunotherapy has been a glorious history of conquering of human diseases. New biotechnological tehniques now allows the production of more potent and safer vaccines.


Copyright © 1986, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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