雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Senile dementia and nucleus basalis of Meynert Imaharu NAKANO 1 , Asao HIRANO 2 1Department of Neurology, Shimoshizu National Hospital 2Division of Neuropathology, Department of Pathology, Montefiore Medical Center pp.612-623
Published Date 1985/8/10
DOI https://doi.org/10.11477/mf.1431905717
  • Abstract
  • Look Inside

 Recent studies of senile dementia of Alzheimer's type (SDAT) have shown that central cholinergic neurons are probably damaged in this condition: 1) disturbance of recent memory, a major symptom of SDAT, transiently develops in normal young people via scopolamine, an anticholinergic agent, 2) patients with SDAT show some improvement of their psychic conditions by administration of physostigmine alone or physostigmine plus lecithin, 3) activity of choline acetyltransferase (CAT), the best presynaptic marker of cholinergic neurons, is markedly reduced in the cerebral cortex of patients with SDAT.


Copyright © 1985, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

関連文献

もっと見る

文献を共有