Axonal flow and colchicine Yoshiaki Komiya 1 1Department of Biochemistry, Institute of Brain Research, Faculty of Medicine, University of Tokyo pp.258-265
Published Date 1982/4/10
DOI https://doi.org/10.11477/mf.1431905387
  • Abstract
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The effects of colchicine on fast axoplasmic transport and slow axonal flow were reviewed. In addition, the auther's experimental results were also presented as follows.

1) Colchicine (4 μg) injected into the rat L5 dorsal root ganglion 10 min before labelingblocked tubulin transport preferentially, with little effect on neurofilament triplet and actin.

2) Colchicine at this dose had no effect on the biosynthesis of tubulin in the ganglion.

3) The inhibitory effect of colchicine on tubulin transport persisted on at least 2 days after the treatment.

Copyright © 1982, Igaku-Shoin Ltd. All rights reserved.


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