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Basic Studies in Cerebral Edema in Relation to Corticosteroid Therapy Shuji Kamano 1 1Dept. of Neurosurgery University of Tokyo School of Medicine pp.968-976
Published Date 1971/11/10
DOI https://doi.org/10.11477/mf.1431903328
  • Abstract
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1) Effect of corticosteroid in different doses on oil-emboli-induced cerebral edema was studied. Initial dose of hydrocortisone may be around 10 mg/kg to give protective effect on "Blood-Brain Barrier", and smaller doses may not exhibit signifi-cant effect.

2) Different ster oid regimens were tried. Delayed startof steroid administration reduces its effect.

3) Effect of prednisolone on cellular membrane was examined by employing cultured astrocytoma cells. Swelling and vacuole-formation of astro-cytoma cellswere prevented by addition of pre-dnisolone to culture medium.


Copyright © 1971, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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