神経鞘細胞性腫瘍の組織像

Histological Features of Tumors of Nerve Sheath, with Special Reference of Neurilemoma and Neurofihroma

I．緒言と文献

1．鞘細胞性腫瘍の特徴

　皮膚腫瘍検片中の良性腫瘍では一般に血管性腫瘍と鞘細胞性腫瘍が多く，殊に後者は種々の方面から精検せられている。之は其の大多数は良性腫瘍なのに其の像が相当雑多性を示すからだろう。結局神経組織は正常でも腫瘍でも組織像が雑多な事が考えられる。従来の研究は鞘細胞の組織発生や鞘細胞性腫瘍が外胚葉由来か，間葉由来か，又其の細別名の可否等が主だが，此の報告はそれ等の細論は避け鞘細胞性腫瘍の諸像の観察結果を述べる。鞘細胞性腫瘍像の成書の説明が案外充分でなく（後述），鞘細胞や鞘細胞性腫瘍の組織発生由来や命名を論ずる前に，鞘細胞性腫瘍の雑多な諸像を充分知る事が検査上重要だと思つたからである。

The auther carried out a histological study of107 cases of Schwann-cell tumors, being illustr-ated by numerous photomicrographs. Variousforms of tumors examined were of 24 cases ofneurilemoma, 54 cases of neurofibroma, 4 casesof combinated form of neurilemoma & neurofi-broma, 2 cases of malignant Schwannoma, 6cases of neuronevus, 8 cases of unusual formsand 9 cases of neuroma. The sections werestained with hematoxylin-eosin and silver impr-egnation. Especially detailed investigations wereperformed on neurilemoma and neurofibroma,being carefully compared microscopical appeara-nces of both tumors.

Excluding the pattern of Verocay body, theremaining greater part of sections of neurilem-oma showed no morphological differences toneurofibroma. Also the definition of Verocaybody becomes very uncertain, when a disturba-nce of regimentary arrangement of nuclei adv-anced. Moreover a gradual transition of histol-ogical features between neurilemoma and neur-ofibroma was observed, as seen in combinatedforms. A summary of the results of the investi-gations quoted in this report leads to the follo-wing conclusions: The main parenchymatouscells of neurilemoma and neurofibroma mightbe essentially identical at all, deriving fromSchwann-cells histologically. It seems reasonableboth tumors to be placed under single oncolog-ical term, which represents the Schwann-cellorigin.