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Role of microglia and astrocytes in autoimmune inflammation in the central nervous system Yoh MATSUMOTO 1 1Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience Keyword: ミクログリア , アストロサイト , 免疫能 pp.551-555
Published Date 2002/8/10
DOI https://doi.org/10.11477/mf.1431901378
  • Abstract
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It is recently known that glial cells in the central nervous system (CNS) have immunological functions when autoimmune inflammation takes place in the CNS. Microglia, macrophage-mimicking resident cells, were first shown to have antigen-presenting ability to neuroantigen-specific T cells, suggesting that microglia promote autoimmune inflammation especially during the early stage of the disease. Moreover, recent studies demonstrated that microglia that had phagocytized apoptotic T cells secrete more IL-10 and TGF-β and down-regulate inflammation at later stages of the disease.


Copyright © 2002, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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