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IL-6 family cytokines, gp130-subfamily receptors and their signal transductions in the brain: An overview. Emiko SENBA 1 , Yoshihiro MORIKAWA 1 , Shinobu TAMURA 1 , Toshio KITAMUEA 2 1Department of Anatomy and Neurobiology, Wakayama Medical University 2Department of Hematopoietic Factors, The Institute of Medical Science, The University of Tokyo Keyword: IL-6familyサイトカイン , gp130-subfamily受容体 , レプチン , TROY pp.909-916
Published Date 2001/12/10
DOI https://doi.org/10.11477/mf.1431901303
  • Abstract
  • Look Inside

Functional receptor complexes for interleukin-6 (IL-6) family cytokines share gp130 as a component critical for signal transduction. The distribution of the receptor components for these cytokines, such as gp130, LIF-Rβ, IL-6-Rα, have been investigated in murine brains. In the cerebellum, Purkinje cells expressed these receptor components. Overexpression of leukemia inhibitory factor (LIF) in mice led to a reduction in calbindin-immunoreactive dendrites of Purkinje cells.


Copyright © 2001, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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