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Cytokines, their receptors, and related signaling pathways Masato Kubo 1,2 1Department Biotechnology, Research Institute for Biological Sciences, Tokyo University of Science Keyword: サイトカイン , 受容体 , シグナル伝達系 pp.585-592
Published Date 2010/6/15
DOI https://doi.org/10.11477/mf.1542102308
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Cytokines has an important communication tool to transfer the information in cell to cell, and this process associates with many aspects of biological phenomenon. There are numerous number of cytokines have been identified in over last two decades and these cytokines are classified 7 group based on the structural conformations of their receptor. The bindings of cytokines to its cognate receptors initiate activation of downstream signaling cascade, and in many case, these signaling was regulated by phospholyration of tyrosine residue on the receptor and related signaling molecules. Most popular and commune one is JAK-STAT pathway, which is utilized by type I and II receptor families. These signaling pathways, including other pathway, play a critical role to determine the cell fate.


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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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