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Gene transfer to neural tissues by HVU-liposomes Yasushi KANEDA 1 1Division of Gene Therapy Science, Department of Molecular Therapeutics, Osaka University Graduate School of Medicine Keyword: 非ウイルスベクター , 遺伝子導入 , 遺伝子治療 pp.38-44
Published Date 2001/2/10
DOI https://doi.org/10.11477/mf.1431901224
  • Abstract
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HVJ-liposome gene delivery system has been effective for in vivo gene transfer. We further developed HVJ-anionic liposomes and HVJ-cationic liposomes. When HVJ-anionic liposomes containing LacZ gene were injected into monkey brain, wide spread LacZ gene expression was detected. Using this method, transfer of bc1-2 gene into ischemic rat brain inhibited the ischemic changes of the brain tissue. On the contrary, using HVJ-cationic liposomes, gene transfer was restricted at the injection site of the brain.


Copyright © 2001, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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