脳動脈瘤の成因と治療に関する研究

The origin of cerebral aneurysms and the future of aneurysms treatment

はじめに

　従来，脳動脈瘤を動物に誘発することはできなかったために，その発生機序を動物モデルを使って研究することはできなかった^14,16）。

　今回，われわれの開発してきた脳動脈瘤誘発動物モデルから得られた知見を紹介し，ここから考えられる脳動脈瘤の発生，増大機序を概説する。また，脳動脈瘤の非手術的治療の可能性について動物実験の結果を示す。

Cerebral aneurysms were induced in rats, later in monkeys too, by ligating the common carotid artery on one side, making the animals hypertensive, and feeding them the lathyrogen β -aminopropionitrile. On analysis of this animal model, hemodynamic stress, hypertension and metabolic disorder of connective tissue proved to be of primary importance as etiological factors. The experimentally induced aneurysms resemble those in man both in location and in microscopic structure. The initial change leading to the formation of aneurysms occurred on the distal side of the major branch adjacent to the apex, and distal to the intimal pad.