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The mechanism of amyloid β-induced neuronal death Akihiko TAKASHIMA 1 1Project Research Center, Mitsubishi Kasei Institute of Life Sciences pp.273-283
Published Date 1996/4/10
DOI https://doi.org/10.11477/mf.1431900741
  • Abstract
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 Pathological changes in Alzheimer's disease are characterized by cerebral cortical atrophy as a result of degeneration and loss of neurons. Typical histological lesions include numerous senile plaques composed of deposits of β-amyloid (Aβ) and neurofibrillary tangles consisting predominantly of ubiquitin and highly phosphorylated tau proteins. In cell culture, exogenous application of synthetic Aβ is known to induce neurotoxic effects in rat hippocampal neurons. Neuronal death induced by Aβ is accompanied by some protein synthesis.


Copyright © 1996, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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