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Japanese

Schizophrenia and the frontal lobe. Michio SUZUKI 1 , Masayoshi KURACHI 1 1Department of Neuropsychiatry, Faculty of Medicine, Toyama Medical and Pharmaceutical University pp.155-166
Published Date 1993/2/10
DOI https://doi.org/10.11477/mf.1431900317
  • Abstract
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Recent advances in methodologies and techniques in neuroscience have made us possible to perform antemortem and postmortem studies in schizophrenic brain, and the pathophysiology of schizo-phrenia has been understood as structural and functional abnormalities of the brain. Several lines of research have suggested that patients with schizophrenia have deficits in frontal lobe function. First, so-called negative symptoms of schizophrenia such as affective flattening, poverty of speech, and loss of drive are similar to many of the clinical manifestations of frontal lobe injury. Secondly, neuropsy-chological studies have demonstrated that schizophrenic patients show poor performance on tests of executive function and attention, suggestive of frontal lobe dysfunction. And thirdly, structural and functional brain imaging studies have found direct evidence of frontal lobe abnormalities in schizo-phrenia.


Copyright © 1993, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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