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Amyloid protein in kuru plaques. Jun TATEISHI 1 , Tetsuyuki KITAMOTO 1 1Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University pp.396-402
Published Date 1990/6/10
DOI https://doi.org/10.11477/mf.1431900039
  • Abstract
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Kuru plaque is a pathological hallmark of “prion diseases”, such as Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), Kuru in New Guinea, and scrapie in various species of animals. The plaque resembles morphologically the senile plaque in Alzheimer's disease, but shows more numerous distribution in the cerebellar cortex and has less argyrophilic crowns than the senile plaque. However, both plaques are accompanied with tau-positive, degenerative neuronal processes, especially in the hippocampus. Immunostains using anti-prion protein (PrP) and anti-β (or A4) protein can identify each plaque.


Copyright © 1990, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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