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Molecular genetic approaches for studying the etiology of psychiatric disorders Tadao Arinami 1 1Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba Keyword: 分子遺伝学 , 精神疾患 , 連鎖解析 , 関連解析 pp.660-672
Published Date 2006/10/10
DOI https://doi.org/10.11477/mf.1431100387
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 The majority of common psychiatric disorders still pose difficulties for geneticists because of their complex and non-Mendelian modes of inheritance. However, substantial progresses have been made in identifying genes associated with psychiatric disorders though genetic linkage and association studies, analyses of families with cosegregation of chromosomal translocations and psychiatric disorders, identifying contiguous gene microdeletion syndrome that increase risks for psychiatric problems and analyses of genetically engineered animal models. Furthermore, recent advance in the knowledge of the entire human genome and haplotype maps of the human genome will allow researchers to find genes and genetic variations that affect higher mental functions and to enable rational haplotype comparisons between studies. In addition, high throughput technologies such as arrays for genome-wide association studies, comparative genomic hybridization(CGH), DNA methylation profiling will lead to major advances in understanding of the molecular basis of mental illness. These formidable tasks will be accomplished by continuing to harness the synergy between human and experimental genetic approaches.


Copyright © 2006, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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