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Neuroimaging diagnosis of prion diseases Akio Kimura 1 , Jin Nishimiya 1 , Tatsuhiko Yuasa 1 1Department of Neurology, Kohnodai Hospital, National Center Neurology & Psychiatry(NCNP) Keyword: プリオン病 , prion disease , 拡散強調画像 , diffusion-weighted MRI , SPECT , MRS pp.137-145
Published Date 2003/2/10
DOI https://doi.org/10.11477/mf.1431100291
  • Abstract
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 We reported the cerebral imaging findings in 5 patients with prion disease and compared with previous reports. Diffusion-weighted MRI(DWI)proved to be particulary useful for early diagnosis of prion disease. DWI revealed abnormal hyperintense lesions particulary cerebral cortex, more sensitively than conventional MRI. DWI appears to be useful to monitor the disease because of the serial changing abnormal signal lesions with progression of the neurological findings. In the case with the point mutation of the codon 180, MRI demonstrated expansion of the high cortical signal on T2-weighted images, which was the same as previous report of the case with the point mutation of the codon 180. SPECT imaging with99mTc-ECD revealed severely decreased perfusion of the area, which MRI revealed high intensity on T2-weighted images. Proton magnetic resonance spectroscopy(H1-MRS)revealed a decrease of N-acetylaspartate signals. But these changes of SPECT and H1-MRS are not specific for prion disease. However, further investigations must be performed to determine the diagnostic value for prion disease.


Copyright © 2003, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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