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Epidemiology of multiple sclerosis in 2006: environmental effects in risk for multiple sclerosis Masami TANAKA 1 1Department of Neurology and MS Center, Utano National Hospital Keyword: 多発性硬化症 , 疫学 , 環境因子 , 細菌 pp.494-502
Published Date 2006/8/10
DOI https://doi.org/10.11477/mf.1431100158
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The pathogenesis of multiple sclerosis(MS)remains unclear, however, genetic factors are believed to be important in disease susceptibility. MS is thought to be primarily a disease of Caucasians whereas certain ethnic groups are resistant. A north to south prevalence gradient found in Europe, the United States(USA), Australia, New Zealand, and Japan may be due to ethnic variation of northern European heritage. Recent studies suggest the effect of northern latitude is much less strong than previously in Europe and USA. The prevalence of MS in most areas of the world increases during recent two decades. The increased number of MS patients may not be due to the development of diagnostic procedures including MRI because the prevalence ratio between men and women decreased. These findings suggest the number of MS patients is increasing and the changes of environmental factors in the population such as virus or bacteria influenced on the prevalence of MS. The immunoregulatory cells including mucosal-associated invariant T(MAIT)cells insufficiently develop by a change of bacterial flora in the intestine, that may be one of the reasons of increased patients with MS.


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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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