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Recent advance in the therapy of brain edema Yukio Ikeda 1 1Department of Neurosurgery, Tokyo Medical University Hachioji Medical Center Keyword: 脳浮腫 , 浸透圧利尿剤 , ステロイド , 脳低温療法 , フリーラジカルスカベンジャー pp.291-304
Published Date 2006/4/10
DOI https://doi.org/10.11477/mf.1431100137
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The pathophysiologic mechanisms of brain edema, defined as an abnormal accumulation of fluid associated with volumetric enlargement of the brain, are complicated and multifactorial. Brain edema is still a serious complication of cerebrovascular disease, brain tumor, head injury, brain abscess and hypoxic injury. Therapeutic options include hyperosmolar solutions such as mannitol, and glycerol, hypertonic solutions, diuretics and steroids. The treatment of peritumoral edema with steroids provides the most consistently beneficial effects. Recently free radical scavengers and brain hypothermia have received much attention in neuroprotective strategy for brain injury and brain edema in clinical practice. Active research into aquaporin and matrix metalloproteinases(MMP)may produce novel therapeutic targets to decrease brain edema. Future research in brain edema biochemical mediators and optimal combinations of therapeutic regimens will be expected to improve management of patients with brain edema.


Copyright © 2006, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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