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Dermatomyositis Kazuma Sugie 1 1Department of Neurology, Nara Medical University School of Medicine Keyword: 皮膚筋炎 , 筋病理 , 筋炎特異的自己抗体 , Ⅰ型インターフェロン , 大量免疫グロブリン , dermatomyositis , muscle biopsy , myositis-specific autoantibody , type I interferon , high-dose immunoglobulin pp.635-645
Published Date 2024/5/1
DOI https://doi.org/10.11477/mf.1416202654
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Abstract

Dermatomyositis (DM) is distinguished from other idiopathic inflammatory myopathies by the characteristic skin rashes, muscle pathology, and muscle symptoms. Five myositis-specific autoantibodies have been identified in DM, and the correlation between each antibody and the clinical picture is clear. Pathological analysis has also identified DM as a type I interferonopathy of the skeletal muscle. Consideration of treatment strategies requires careful evaluation of muscle strength, systemic inflammatory findings, muscle pathology, muscle imaging, and complications such as malignancy and interstitial lung disease. Corticosteroids are administered as first-line treatment, and immunosuppressive agents and intravenous immunoglobulins are employed as important second-line treatments. Some patients exhibit resistance to these therapies. Currently, treatment strategies for refractory cases are not well established, necessitating further development of treatment methods.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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